The research, published in the journals Proceedings of the National Academy of Sciences (PNAS) and Molecular Biosystems, was led by research groups headed by William Gerwick of the Center for Marine Biotechnology and Biomedicine at Scripps Institution of Oceanography at UC San Diego and the UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, and Pieter [...]
The Duke team proved that if the switch is on, then a cell will divide, even if it’s damaged or the signal to grow disappears. Showing how the switch works may provide clues to novel drug targets for cancer and other diseases in which cell growth goes awry.
The switch is part of a critical pathway [...]
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Diabetes is undergoing a genetics revolution that suggests there are many subtypes of the disease.
The discoveries already trigger important changes in treatment for a fraction of patients with some rare diabetes types caused by single genes gone awry - if they have a doctor aware of the findings.
“We’ve got a whole group [...]
Tests on mice show that diacetyl, a component of artificial butter flavouring, can cause a condition known as lymphocytic bronchiolitis, said the team at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.
The condition can lead to obliterative bronchiolitis — or popcorn lung — a rare and debilitating disease seen [...]
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This isn’t just a curiosity for jazz fans but a bold experiment in the neuroscience of music, a field that’s booming as researchers realize that music illuminates how the brain works. How we play and hear music provides a window into most everyday cognitive functions - from attention to emotion to memory [...]
This imaging technology is one of many new ways of detecting cancers in the body in real time, said Christopher Contag, PhD, associate professor of pediatrics and of microbiology and of immunology, who led the study. Contag said he hoped it might be one of the first to be used routinely for early detection of [...]
As with mice, the TEX11 gene is also located on the human X chromosome. Given that disruption of TEX11 causes azoospermia, or non-measurable sperm levels in mice, mutations in the human TEX11 gene may be a genetic cause of infertility in men. Because men have only one X chromosome that they inherit from their mother [...]
Damage from both diseases was prevented and even reversed when the protein, Robo4, was activated in mice models that simulate age-related macular degeneration (AMD) and diabetic retinopathy, according to Dean Y. Li, M.D., Ph.D., senior author of the study published March 16 in Nature Medicine online.
Robo4 treated and prevented the diseases by inhibiting abnormal blood [...]
%26quot;What we are finding is that about 60% of people, one year after severe infection with West Nile, still report symptoms,%26quot; says Kristy Murray of the University of Texas Health Science Center at Houston, a lead researcher on the study.
Supported by a grant from the National Institutes of Health (NIH), Murray and her colleagues have [...]
Then there is the alarm-ringing death of a potentially dangerous cell, such as a cell infected with Salmonella, they added. These dying cells spill chemical signals and get a protective response. The resulting inflammation, which the body launches in self-defense, can at times backfire and damage vital tissues.
A research team lead by Dr. Brad T. [...]
